Volume-Sensitive Chloride Channels Do Not

Mediate Activation-Induced Chloride Efflux Volume-Sensitive Chloride Channels Do Not

Volume-sensitive chloride channels associated with human cervical carcinogenesis.

Previous controversy has risen from the purported equivalence of the volume-sensitive chloride channels with P-glycoprotein. The aim of this study was to investigate the association between expression of volume-sensitive Cl- channels and the process of malignant transformation of cervical epithelial cells. We studied the activations of volume-sensitive and cAMP-mediated chloride currents in var...

Anti-nociceptive effect of cimetidine in mice: the role of ATP-sensitive potassium channels

Recent studies have shown that intracerebroventricular administration of cimetidine (CIM) induces anti-nociceptive and anti–inflammatory effects in rats. However, the underlying mechanism of CIM effect has not been determined yet. This study was planned to determine the anti-nociceptive effect of CIM (50 mg/kg, i.p.) in male mice (25-30 g, n = 80) using tail flick test. Also, the role of ATP-se...

Perspective: The List of Potential Volume-sensitive Chloride Currents Continues to Swell (and Shrink)

The protein for the swelling-activated chloride conductance is one of the few ion channels left for which we do not have a universally acceptable clone. In this brief note, I hope to describe why chloride channels in general, and I Cl.swell in particular, have been difficult to pin down. Dr. Strange describes why he believes the pICln protein is not I Cl.swell . I agree. In 1995 we demonstrated...

Activation of volume-sensitive Cl(-) channel is involved in carboplatin-induced apoptosis in human lung adenocarcinoma cells.

The purpose of the present study is to observe the role of volume-sensitive Cl(-) channels in carboplatin-induced apoptosis in the human lung adenocarcinoma cell line A549 cells. Using patch clamp and apoptosis assays, we found that A549 cells underwent the process of apoptotic volume decrease (AVD) and apoptosis when treated with carboplatin or staurosporine (STS). This AVD and apoptosis proce...